Concept
lung mechanics
Parents
Children
Acute Respiratory Distress SyndromeArtificial RespirationChronic CareLung HealthLung Management
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1.7M
Citations
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Authors
8.2K
Institutions
Pulmonary Mechanical Pathophysiology
1927 - 1945
A period characterized by mechanistic inquiry into how airway resistance, lung compliance, and gas-exchange physiology shape outcomes across traumatic, infectious, developmental, and postoperative conditions. The era marks a unifying emphasis on how structural and functional maturation of the lung governs vulnerability to atelectasis, hypoxemia, and ventilation-perfusion mismatch, while establishing quantitative links between mechanical forces and physiological responses.
• Atelectasis and lung collapse emerge as a central investigative thread, linking traumatic, surgical, and postoperative conditions with imaging- and physiology-based characterizations of collapse patterns, roentgen shadows, and mechanism-of-failure in air entry [1] [9] [2] [13] [10] [17].
• Research converges on how airway resistance interfaces with pulmonary blood flow, revealing rapid cardiovascular and respiratory responses, respiratory acidosis/alkalosis during obstruction or embolism, and heart-lung coupling in asthma and post-injury states [5] [4] [14] [3].
• Pathology and imaging frameworks for atypical pneumonia emerge, distinguishing infection subtypes and unknown etiologies through histology, roentgenology, and clinical description, highlighting evolving disease concepts and differential diagnoses [6] [11] [19] [15].
• Developmental and anatomical variation studies track alveolar formation, neonatal lung physiology, and congenital agenesis, tying structural maturation to metabolic and respiratory function across infancy to childhood [8] [16] [20].
• Gas-exchange physiology under variable body size and oxygen conditions is explored, linking nitrogen elimination, CO2 tension, hydrogen ion balance, and high-oxygen breathing to whole-lung function across individuals [7] [14] [16].
Mid-Century Quantitative Lung Mechanics
1946 - 1972
Pediatric Lung Mechanics Standardization
1973 - 1979
Ventilation-Induced Lung Mechanics
1980 - 1997
Biotrauma Driven Ventilation
1998 - 2004
Mechanics-Driven Lung Development
2005 - 2011
Lung Mechanics Mechanobiology
2012 - 2024